Compounded NAD+ Injection
NAD+ (nicotinamide adenine dinucleotide) is an injectable form of a naturally occurring coenzyme involved in cellular energy metabolism, delivered by subcutaneous injection, with published research evaluating NAD+ and related pathways across metabolic and age-related contexts.
Compounded medications are not FDA-approved and have not been evaluated by the FDA for safety, effectiveness, or quality prior to dispensing
NAD+ is administered by subcutaneous injection, typically in the abdomen or thigh. Your physician will determine the dose and frequency based on your clinical evaluation.
Compounded NAD+ injection has limited human safety data, so side effects are described conservatively based on available NAD+ tolerability research and general injection-safety considerations. Potential side effects may include nausea, abdominal discomfort, diarrhea, sudden bowel urgency, vomiting, headache, fatigue, dizziness, flushing or hot flashes, muscle cramping or tightness, weakness, changes in heart rate, palpitations, chest pressure or tightness, and feeling unwell after administration.
Because compounded NAD+ is administered by injection, injection-related side effects can include pain, redness, swelling, itching, bruising, bleeding, warmth, irritation, tenderness, infection, or an allergic reaction at or near the injection site. Contact your provider if side effects are persistent, worsening, or concerning, and seek urgent medical care for chest pain, severe shortness of breath, fainting, severe dizziness, severe allergic reaction, swelling of the face or throat, wheezing, or any sudden or severe symptoms after an injection.
You are encouraged to report negative side effects of prescription products:
- Contact FDA MedWatch at 1-800-FDA-1088 or visit www.fda.gov/medwatch
The statements on this page have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Important Safety Information
Important Safety Information — Compounded NAD+ Injection
What is this?
This Important Safety Information summarizes key warnings, precautions, possible side effects, and general safety considerations for compounded NAD+ injection.
This page does not include all possible information about compounded NAD+ injection. Always follow your prescription label, pharmacy instructions, and the instructions provided by your ATHS healthcare provider.
Compounded NAD+ injection is not FDA-approved. The FDA does not review compounded medications for safety, effectiveness, or quality before they are dispensed. Compounded medications may be prescribed when a licensed healthcare provider determines that a compounded preparation is medically appropriate for a specific patient.
NAD+ stands for nicotinamide adenine dinucleotide, a naturally occurring coenzyme involved in cellular metabolism and other biological processes. Human safety data specific to compounded NAD+ injection are limited.
Important limitations of available safety information
There is limited published human safety information specific to compounded NAD+ injection. Side effects, tolerability, exposure, and risk may vary depending on the dose, formulation, route of administration, patient health history, and other medications or supplements used by the patient.
Because the full safety profile of compounded NAD+ injection has not been established, patients should use it only as directed and should report unusual, persistent, worsening, or concerning symptoms to their healthcare provider.
Who should not use compounded NAD+ injection?
Do not use compounded NAD+ injection if you have had a known hypersensitivity or allergic reaction to NAD+, nicotinamide-related compounds, or any ingredient in the compounded preparation.
Do not use compounded NAD+ injection if the medication appears contaminated, discolored, cloudy, crystallized, leaking, damaged, or otherwise unusual.
Compounded NAD+ injection may not be appropriate for patients with certain cardiovascular conditions, unstable blood pressure, active severe illness, significant kidney or liver disease, pregnancy, breastfeeding, or a history of serious reactions to injectable medications unless specifically reviewed by a healthcare provider.
Before using compounded NAD+ injection
Tell your healthcare provider about all medical conditions, including heart disease, chest pain, abnormal heart rhythm, high or low blood pressure, fainting episodes, kidney disease, liver disease, diabetes, seizure history, asthma, severe allergies, pregnancy, breastfeeding, or any history of reactions to injectable medications.
Tell your healthcare provider about all medications and supplements you take, including prescription medications, over-the-counter medications, vitamins, supplements, stimulants, blood pressure medications, diabetes medications, anticoagulants, and medications that affect heart rhythm.
Possible side effects
Possible side effects associated with compounded NAD+ injection may include nausea, abdominal discomfort, stomach cramping, diarrhea, sudden bowel urgency, vomiting, headache, fatigue, dizziness, flushing or hot flashes, muscle cramping, muscle tightness, weakness, changes in heart rate, palpitations, chest pressure, chest tightness, and feeling unwell after administration.
Because compounded NAD+ is administered by injection, injection-related side effects may include pain, redness, swelling, itching, bruising, bleeding, warmth, irritation, tenderness, infection, or skin reaction at the injection site.
Side effects may vary based on dose, concentration, frequency of use, individual sensitivity, medical history, hydration status, and other medications or supplements being used.
Cardiovascular symptoms
Compounded NAD+ injection may be associated with symptoms such as palpitations, changes in heart rate, dizziness, lightheadedness, chest pressure, chest tightness, or unusual blood pressure changes.
Contact your healthcare provider if you experience palpitations, elevated heart rate, dizziness, lightheadedness, chest discomfort, unusual blood pressure changes, or symptoms that recur after dosing.
Seek urgent medical care for chest pain, severe shortness of breath, fainting, severe dizziness, symptoms of stroke, or any sudden or severe cardiovascular symptom.
Gastrointestinal symptoms
Gastrointestinal symptoms may include nausea, vomiting, abdominal discomfort, stomach cramping, diarrhea, gas, sudden bowel urgency, or feeling queasy.
Contact your healthcare provider if gastrointestinal symptoms are severe, persistent, worsening, or associated with dehydration, dizziness, fainting, or inability to keep fluids down.
Injection site reactions
Injection site reactions may include pain, redness, itching, bruising, bleeding, swelling, warmth, tenderness, irritation, or a lump at the injection site.
Contact your healthcare provider if an injection site reaction is severe, spreading, worsening, warm to the touch, draining fluid, associated with fever, or does not improve.
Allergic reactions
Allergic reactions may occur with injectable medications. Symptoms may include rash, itching, hives, swelling, dizziness, wheezing, chest tightness, or trouble breathing.
Do not use additional doses if you suspect an allergic reaction unless directed by a healthcare provider.
Laboratory and monitoring considerations
Human safety data for compounded NAD+ injection are limited, and the long-term safety profile has not been fully established.
Your healthcare provider may recommend monitoring based on your medical history, symptoms, dose, frequency of use, and treatment plan.
Drug and supplement interactions
Formal drug-interaction studies for compounded NAD+ injection are limited. Tell your healthcare provider about all medications and supplements you take before using compounded NAD+ injection.
Use caution if you take medications or supplements that affect blood pressure, heart rate, blood sugar, blood clotting, kidney function, liver function, or nervous system activity unless reviewed by your healthcare provider.
Pregnancy
The safety of compounded NAD+ injection during pregnancy has not been established. Tell your healthcare provider if you are pregnant, planning to become pregnant, or think you may be pregnant before using compounded NAD+ injection.
Breastfeeding
The safety of compounded NAD+ injection while breastfeeding has not been established. Tell your healthcare provider if you are breastfeeding or planning to breastfeed before using compounded NAD+ injection.
Use in pediatric or geriatric patients
The safety and effectiveness of compounded NAD+ injection have not been established in pediatric patients.
Older adults or patients with chronic medical conditions may require more cautious evaluation before using compounded NAD+ injection because published injection-specific safety data are limited.
Missed Dose
If you miss a dose, follow the instructions on your prescription label or contact your healthcare provider or pharmacy.
Do not use extra compounded NAD+ injection to make up for a missed dose. Do not change your dosing schedule without medical direction.
Overdose
Using too much compounded NAD+ injection, or using it more often than directed, may increase the risk of side effects, including nausea, diarrhea, abdominal cramping, vomiting, headache, dizziness, flushing, palpitations, changes in heart rate, chest pressure, injection site reactions, or other symptoms.
In case of overdose or accidental exposure, seek medical attention immediately or contact Poison Control at 1-800-222-1222.
Storage
Follow the storage instructions provided by your pharmacy.
Unless your prescription label or pharmacy instructions state otherwise, store medication as directed by the dispensing pharmacy, away from excessive heat, moisture, and direct light.
In general:
- Store medication at the temperature listed on the prescription label.
- Keep away from excessive heat, moisture, and direct light.
- Keep out of reach of children and pets.
- Do not use medication that appears contaminated, discolored, damaged, crystallized, cloudy, leaking, or otherwise unusual.
- If using injectable medication, use only as instructed and dispose of needles and syringes in an appropriate sharps container.
Medication Disposal
Do not flush unused medication down the toilet or pour it into a sink or drain unless specifically instructed.
Preferred disposal method:
- Use a DEA-authorized drug take-back location when available.
- If no take-back option is available, follow local disposal guidance or ask your pharmacist for instructions.
For injectable supplies, place needles and syringes in an approved sharps container. Do not place loose needles directly into household trash.
When to contact your provider
Contact your healthcare provider if you experience persistent nausea, vomiting, diarrhea, abdominal cramping, headache, fatigue, dizziness, flushing, palpitations, unusual blood pressure changes, changes in heart rate, chest pressure, injection site reactions, signs of infection, or any side effect that feels unusual, persistent, worsening, or concerning.
Seek urgent medical care
Seek urgent medical care if you experience chest pain, severe shortness of breath, fainting, severe dizziness, severe allergic reaction, swelling of the face or throat, wheezing, symptoms of stroke, severe weakness, or any sudden or severe symptoms after using compounded NAD+ injection.
Reporting Side Effects
Tell your healthcare provider if you experience side effects or symptoms that concern you.
You may report suspected adverse reactions or product quality concerns to the FDA through MedWatch at 1-800-FDA-1088 or www.fda.gov/medwatch.
Telemedicine Disclosure
This prescription may be issued through telemedicine after review by a licensed healthcare provider. If you experience concerning symptoms, contact your ATHS provider or seek emergency medical care.
Withholding or providing inaccurate information about your symptoms, medical history, medications, substance use, allergies, prior reactions, pregnancy status, breastfeeding status, or other relevant health information may result in serious harm.
Disclaimer
This information is not comprehensive and does not include all possible risks, side effects, interactions, warnings, or precautions associated with compounded NAD+ injection. This page does not provide medical advice, diagnosis, or treatment.
Compounded NAD+ injection is prescribed only when a licensed healthcare provider determines that it is medically appropriate. Compounded medications are not FDA-approved and are not reviewed by the FDA for safety, effectiveness, or quality before dispensing.
For questions about your medication, prescription, dosing, side effects, or treatment plan, contact your healthcare provider or pharmacist.
Why NAD+ with ATHS?
Because effective treatment should be accessible from home and backed by real clinical oversight.
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